Advertisement
Review Article| Volume 18, ISSUE 2, P201-214, April 2023

Gastro-Enteric-Pancreatic Neuroendocrine Tumor Treatment

177Lu-DOTATATE

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to PET Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Dasari A.
        • Shen C.
        • Halperin D.
        • et al.
        Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States.
        JAMA Oncol. 2017; 3: 1335-1342
        • Oronsky B.
        • Ma PC
        • Morgensztern D.
        • et al.
        Nothing but NET: a review of neuroendocrine tumors and carcinomas.
        Neoplasia. 2017; 19: 991-1002
        • Krenning E.P.
        • Kwekkeboom DJ
        • Oei HY
        • et al.
        Somatostatin receptor imaging of endocrine gastrointestinal tumors.
        Schweiz Med Wochenschr. 1992; 122: 634-637
        • Reubi JC
        • Schaer JC
        • Waser B.
        • et al.
        Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization.
        Cancer Res. 1994; 54: 3455-3459
        • Sanli Y.
        • Garg I.
        • Kandathil A.
        • et al.
        Neuroendocrine tumor diagnosis and management: (68)Ga-DOTATATE PET/CT.
        AJR Am J Roentgenol. 2018; 211: 267-277
        • Strosberg JR
        • Caplin ME
        • Kunz PL
        • et al.
        (177)Lu-Dotatate plus long-acting octreotide versus high-dose long-acting octreotide in patients with midgut neuroendocrine tumours (NETTER-1): final overall survival and long-term safety results from an open-label, randomised, controlled, phase 3 trial.
        Lancet Oncol. 2021; 22: 1752-1763
        • Hicks RJ
        • Kwekkeboom DJ
        • Krenning E.
        • et al.
        ENETS consensus guidelines for the standards of care in neuroendocrine neoplasia: peptide receptor radionuclide therapy with radiolabeled somatostatin analogues.
        Neuroendocrinology. 2017; 105: 295-309
        • Hope TA
        • Bodei L.
        • Chan JA
        • et al.
        NANETS/SNMMI consensus statement on patient selection and appropriate Use of (177)Lu-DOTATATE peptide receptor radionuclide therapy.
        J Nucl Med. 2020; 61: 222-227
        • Pavel M.
        • Öberg K.
        • Falconi M.
        • et al.
        Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
        Ann Oncol. 2020; 31: 844-860
        • Inzani F.
        • Petrone G.
        • Rindi G.
        The New World Health Organization classification for pancreatic neuroendocrine neoplasia.
        Endocrinol Metab Clin North Am. 2018; 47: 463-470
        • Brunner P.
        • Jörg AC
        • Glatz K.
        • et al.
        The prognostic and predictive value of sstr2-immunohistochemistry and sstr2-targeted imaging in neuroendocrine tumors.
        Eur J Nucl Med Mol Imaging. 2017; 44: 468-475
        • Satapathy S.
        • Mittal B.R.
        177Lu-DOTATATE peptide receptor radionuclide therapy versus Everolimus in advanced pancreatic neuroendocrine tumors: a systematic review and meta-analysis.
        Nucl Med Commun. 2019; 40: 1195-1203
        • Sundin A.
        • Sundin R.
        • Baudin E.
        • et al.
        ENETS consensus guidelines for the standards of care in neuroendocrine tumors: radiological, nuclear medicine & hybrid imaging.
        Neuroendocrinology. 2017; 105: 212-244
        • Bahri H.
        • Laurence L.
        • Edeline J.
        • et al.
        High prognostic value of 18F-FDG PET for metastatic gastroenteropancreatic neuroendocrine tumors: a long-term evaluation.
        J Nucl Med. 2014; 55: 1786-1790
        • Binderup T.
        • Knigge U.
        • Loft A.
        • et al.
        18F-fluorodeoxyglucose positron emission tomography predicts survival of patients with neuroendocrine tumors.
        Clin Cancer Res. 2010; 16: 978-985
        • Binderup T.
        • Knigge U.
        • Johnbeck CB
        • et al.
        (18)F-FDG PET is superior to who grading as a prognostic tool in neuroendocrine neoplasms and useful in guiding PRRT: a prospective 10-year follow-up study.
        J Nucl Med. 2021; 62: 808-815
        • Has Simsek D.
        • Kuyumcu S.
        • Turkmen C.
        • et al.
        Can complementary 68Ga-DOTATATE and 18F-FDG PET/CT establish the missing link between histopathology and therapeutic approach in gastroenteropancreatic neuroendocrine tumors?.
        J Nucl Med. 2014; 55: 1811-1817
        • Binderup T.
        • Knigge U.
        • Loft A.
        • et al.
        Functional imaging of neuroendocrine tumors: a head-to-head comparison of somatostatin receptor scintigraphy, 123I-MIBG scintigraphy, and 18F-FDG PET.
        J Nucl Med. 2010; 51: 704-712
        • Chan DL
        • Pavlakis N.
        • Schembri GP
        • et al.
        Dual somatostatin receptor/FDG PET/CT imaging in metastatic neuroendocrine tumours: proposal for a novel grading scheme with prognostic significance.
        Theranostics. 2017; 7: 1149-1158
        • Kwekkeboom DJ
        • Herder WW
        • Kam BL
        • et al.
        Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0, Tyr3] octreotate: toxicity, efficacy, and survival.
        J Clin Oncol. 2008; 26
        • Bodei L.
        • Cremonesi M.
        • Grana CM
        • et al.
        Peptide receptor radionuclide therapy with 177Lu-DOTATATE: the IEO phase I-II study.
        Eur J Nucl Med Mol Imaging. 2011; 38: 2125-2135
        • Sansovini M.
        • Severi S.
        • Ambrosetti A.
        • et al.
        Treatment with the radiolabelled somatostatin analog Lu-DOTATATE for advanced pancreatic neuroendocrine tumors.
        Neuroendocrinology. 2013; 97: 347-354
        • Sansovini M.
        • Severi S.
        • Ianniello A.
        • et al.
        Long-term follow-up and role of FDG PET in advanced pancreatic neuroendocrine patients treated with 177Lu-D OTATATE.
        Eur J Nucl Med Mol Imaging. 2017; 44: 490-499
        • Delpassand ES
        • Samarghandi A.
        • Zamanian S.
        • et al.
        Peptide receptor radionuclide therapy with 177Lu-DOTATATE for patients with somatostatin receptor-expressing neuroendocrine tumors: the first US phase 2 experience.
        Pancreas. 2014; 43: 518-525
        • Paganelli G.
        • Sansovini M.
        • Ambrosetti A.
        • et al.
        177 Lu-Dota-octreotate radionuclide therapy of advanced gastrointestinal neuroendocrine tumors: results from a phase II study.
        Eur J Nucl Med Mol Imaging. 2014; 41: 1845-1851
        • Paganelli G.
        • Sansovini M.
        • Nicolini S.
        • et al.
        (177)Lu-PRRT in advanced gastrointestinal neuroendocrine tumors: 10-year follow-up of the IRST phase II prospective study.
        Eur J Nucl Med Mol Imaging. 2021; 48: 152-160
        • Sabet A.
        • Dautzenberg K.
        • Haslerud T.
        • et al.
        Specific efficacy of peptide receptor radionuclide therapy with (177)Lu-octreotate in advanced neuroendocrine tumours of the small intestine.
        Eur J Nucl Med Mol Imaging. 2015; 42: 1238-1246
        • Zandee WT
        • Brabander T.
        • Blažević A.
        • et al.
        Symptomatic and radiological response to 177Lu-DOTATATE for the treatment of functioning pancreatic neuroendocrine tumors.
        J Clin Endocrinol Metab. 2019; 104: 1336-1344
        • Sistani G.
        • Sutherland DEK
        • Mujoomdar A.
        • et al.
        Efficacy of (177)Lu-dotatate induction and maintenance therapy of various types of neuroendocrine tumors: a phase II registry study.
        Curr Oncol. 2020; 28: 115-127
        • Satapathy S.
        • Mittal BR
        • Sood A.
        • et al.
        Peptide receptor radionuclide therapy as first-line systemic treatment in advanced inoperable/metastatic neuroendocrine tumors.
        Clin Nucl Med. 2020; 45: e393-e399
        • Parghane RV
        • Bhandare M.
        • Chaudhari V.
        • et al.
        Surgical feasibility, determinants, and overall efficacy of neoadjuvant (177)Lu-DOTATATE PRRT for locally advanced unresectable gastroenteropancreatic neuroendocrine tumors.
        J Nucl Med. 2021; 62: 1558-1563
        • Kudo A.
        • Tateishi U.
        • Yoshimura R.
        • et al.
        Safety and response after peptide receptor radionuclide therapy with (177) Lu-DOTATATE for neuroendocrine tumors in phase 1/2 prospective Japanese trial.
        J Hepatobiliary Pancreat Sci. 2022; 29: 487-499
        • Strosberg J.
        • El-Haddad G.
        • Wolin E.
        • et al.
        Phase 3 trial of 177Lu-Dotatate for midgut neuroendocrine tumors.
        New Engl J Med. 2017; 376: 125-135
        • Frilling A.
        • Modlin IM
        • Kidd M.
        • et al.
        Recommendations for management of patients with neuroendocrine liver metastases.
        Lancet Oncol. 2014; 15: e8-e21
        • Riihimaki M.
        • Hemminki A.
        • Sundquist K.
        • et al.
        The epidemiology of metastases in neuroendocrine tumors.
        Int J Cancer. 2016; 139: 2679-2686
        • Yao JC
        • Hassan M.
        • Phan A.
        • et al.
        One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States.
        J Clin Oncol. 2008; 26: 3063-3072
        • Lehrman ED
        • Fidelman N.
        Liver-directed therapy for neuroendocrine tumor liver metastases in the era of peptide receptor radionuclide therapy.
        Semin Intervent Radiol. 2020; 37: 499-507
        • Dermine S.
        • Palmieri LJ
        • Lavolé J.
        • et al.
        Non-pharmacological therapeutic options for liver metastases in advanced neuroendocrine tumors.
        J Clin Med. 2019; 8
        • Pavel M.
        • O’Toole D.
        • Costa F.
        • et al.
        ENETS consensus guidelines update for the management of distant metastatic disease of intestinal, pancreatic, bronchial neuroendocrine neoplasms (NEN) and NEN of unknown primary site.
        Neuroendocrinology. 2016; 103: 172-185
        • de Baere T.
        • Deschamps F.
        • Tselikas L.
        • et al.
        GEP-NETS update: interventional radiology: role in the treatment of liver metastases from GEP-NETs.
        Eur J Endocrinol. 2015; 172: R151-R166
        • Bhagat N.
        • Reyes DK
        • Lin M.
        • et al.
        Phase II study of chemoembolization with drug-eluting beads in patients with hepatic neuroendocrine metastases: high incidence of biliary injury.
        Cardiovasc Intervent Radiol. 2013; 36: 449-459
        • Turkmen C.
        • Ucar A.
        • Poyanlı A.
        • et al.
        Initial outcome after selective intraarterial radionuclide therapy with yttrium-90 microspheres as salvage therapy for unresectable metastatic liver disease.
        Cancer Biother Radiopharm. 2013; 28: 534-540
        • Roche A.
        • Girish BV
        • Baere T.
        • et al.
        Prognostic factors for chemoembolization in liver metastasis from endocrine tumors.
        Hepatogastroenterology. 2004; 51: 1751-1756
        • Chen JX
        • Rose S.
        • White SB
        • et al.
        Embolotherapy for neuroendocrine tumor liver metastases: prognostic factors for hepatic progression-free survival and overall survival.
        Cardiovasc Interv Radiol. 2017; 40: 69-80
        • Kacmaz E.
        • Heidsma CM
        • Besselink MGH
        • et al.
        Treatment of liver metastases from midgut neuroendocrine tumours: a systematic review and meta-analysis.
        J Clin Med. 2019; 8
        • Strosberg J.
        • Hendifar A.
        • Yao JC
        • et al.
        Impact of liver tumor burden on therapeutic effect of 177Lu-dotatate treatment in NETTER-1 study.
        Ann Oncol. 2018; 29: viii471
        • Braat A.
        • Ahmadzadehfar H.
        • Kappadath SC
        • et al.
        Radioembolization with (90)Y resin microspheres of neuroendocrine liver metastases after initial peptide receptor radionuclide therapy.
        Cardiovasc Intervent Radiol. 2020; 43: 246-253
        • Ezziddin S.
        • Meyer C.
        • Kahancova S.
        • et al.
        90Y Radioembolization after radiation exposure from peptide receptor radionuclide therapy.
        J Nucl Med. 2012; 53: 1663-1669
        • Yilmaz E.
        • Engin MN
        • Ozkan ZG
        • et al.
        Y90 selective internal radiation therapy and peptide receptor radionuclide therapy for the treatment of metastatic neuroendocrine tumors: combination or not?.
        Nucl Med Commun. 2020; 41: 1242-1249
        • Braat A.
        • Bruijnen RCG
        • Rooij RV
        • et al.
        Additional holmium-166 radioembolisation after lutetium-177-dotatate in patients with neuroendocrine tumour liver metastases (HEPAR PLuS): a single-centre, single-arm, open-label, phase 2 study.
        Lancet Oncol. 2020; 21: 561-570
        • Kashyap R
        • Hofman MS
        • Michael M
        • et al.
        Favourable outcomes of (177)Lu-octreotate peptide receptor chemoradionuclide therapy in patients with FDG-avid neuroendocrine tumours.
        Eur J Nucl Med Mol Imaging. 2015; 42: 176-185
        • Ballal S.
        • Yadav MP
        • Damle NA
        • et al.
        Concomitant 177Lu-DOTATATE and capecitabine therapy in patients with advanced neuroendocrine tumors: a long-term-outcome, toxicity, survival, and quality-of-life study.
        Clin Nucl Med. 2017; 42: e457-e466
        • Nicolini S.
        • Bodei L.
        • Bongiovanni A.
        • et al.
        Combined use of 177Lu-DOTATATE and metronomic capecitabine (Lu-X) in FDG-positive gastro-entero-pancreatic neuroendocrine tumors.
        Eur J Nucl Med Mol Imaging. 2021; 48: 3260-3267
        • Lassmann M.
        • Hänscheid H.
        • Chiesa C.
        • et al.
        EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry I: blood and bone marrow dosimetry in differentiated thyroid cancer therapy.
        Eur J Nucl Med Mol Imaging. 2008; 35: 1405-1412
        • Sjögreen Gleisner K.
        • Chouin N.
        • Gabina PM
        • et al.
        EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands.
        Eur J Nucl Med Mol Imaging. 2022; 49: 1778-1809
        • Kesavan M.
        • Turner JH
        Myelotoxicity of peptide receptor radionuclide therapy of neuroendocrine tumors: a decade of experience.
        Cancer Biother Radiopharm. 2016; 31: 189-198
        • Garske-Román U.
        • Sandström M.
        • Baron KF
        • et al.
        Prospective observational study of 177Lu-DOTA-octreotate therapy in 200 patients with advanced metastasized neuroendocrine tumours (NETs): feasibility and impact of a dosimetry-guided study protocol on outcome and toxicity.
        Eur J Nucl Med Mol Imaging. 2018; 45: 970-988
        • Svensson J.
        • Rydén T.
        • Hagmarker L.
        • et al.
        A novel planar image-based method for bone marrow dosimetry in (177)Lu-DOTATATE treatment correlates with haematological toxicity.
        EJNMMI Phys. 2016; 3: 21
        • Hagmarker L.
        • Svensson J.
        • Rydén T.
        • et al.
        Bone marrow absorbed doses and correlations with hematologic response during 177Lu-DOTATATE treatments are influenced by image-based dosimetry method and presence of skeletal metastases.
        J Nucl Med. 2019; 60: 1406-1413
        • Vegt E.
        • Jong M.
        • Wetzels JFM
        • et al.
        Renal toxicity of radiolabeled peptides and antibody fragments: mechanisms, impact on radionuclide therapy, and strategies for prevention.
        J Nucl Med. 2010; 51: 1049-1058
        • Dawson LA
        • Kavanagh BD
        • Paulino AC
        • et al.
        Radiation-associated kidney injury.
        Int J Radiat Oncol Biol Phys. 2010; 76: S108-S115
        • Emami B.
        • Lyman J.
        • Brown A.
        • et al.
        Tolerance of normal tissue to therapeutic irradiation.
        Int J Radiat Oncol Biol Phys. 1991; 21: 109-122
        • Sandstrom M.
        • Garske-Román U.
        • Granberg D.
        • et al.
        Individualized dosimetry of kidney and bone marrow in patients undergoing 177Lu-DOTA-octreotate treatment.
        J Nucl Med. 2013; 54: 33-41
        • Sundlöv A.
        • Gustafsson J.
        • Brolin G.
        • et al.
        Feasibility of simplifying renal dosimetry in 177Lu peptide receptor radionuclide therapy.
        EJNMMI Phys. 2018; 5: 1-19
        • Sundlöv A.
        • Sjögreen-Gleisner K.
        • Svensson J.
        • et al.
        Individualised (177)Lu-DOTATATE treatment of neuroendocrine tumours based on kidney dosimetry.
        Eur J Nucl Med Mol Imaging. 2017; 44: 1480-1489
        • Cremonesi M.
        • Ferrari ME
        • Bodei L.
        • et al.
        Correlation of dose with toxicity and tumour response to (90)Y- and (177)Lu-PRRT provides the basis for optimization through individualized treatment planning.
        Eur J Nucl Med Mol Imaging. 2018; 45: 2426-2441
        • Marin G.
        • Vanderlinden B.
        • Karfis I.
        • et al.
        A dosimetry procedure for organs-at-risk in 177Lu peptide receptor radionuclide therapy of patients with neuroendocrine tumours.
        Physica Med. 2018; 56: 41-49