Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to PET ClinicsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Neuroinflammation: the role and consequences.Neurosci Res. 2014; 79: 1-12
- How neuroinflammation contributes to neurodegeneration.Science. 2016; 353: 777-783
- Emerging PET radiotracers and targets for imaging of neuroinflammation in neurodegenerative diseases: outlook beyond TSPO.Mol Imaging. 2018; 17 (1536012118792317)
- Recent developments in TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders.Int J Mol Sci. 2019; 20: 3161
- Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain.Mediators Inflamm. 2013; 2013: 480739
- Neuroinflammation induces neurodegeneration.J Neurol Neurosurg Spine. 2016; 1: 1003
- Defining “neuroinflammation”.Ann N Y Acad Sci. 2008; 1139: 318-330
- Innate immune activation in neurodegenerative disease.Nat Rev Immunol. 2014; 14: 463-477
- Neuroinflammation: the devil is in the details.J Neurochem. 2016; 139: 136-153
- Mechanisms underlying inflammation in neurodegeneration.Cell. 2010; 140: 918-934
- Microglia and mast cells: two tracks on the road to neuroinflammation.FASEB J. 2012; 26: 3103-3117
- Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases.J Neuroimmunol. 2014; 274: 1-13
- Imaging and fluid biomarkers in frontotemporal dementia.Nat Rev Neurol. 2017; 13: 406-419
- The blood-brain barrier in health and chronic neurodegenerative disorders.Neuron. 2008; 57: 178-201
- Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders.Nat Rev Neurol. 2018; 14: 133-150
- In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation.Theranostics. 2018; 8: 2603-2620
- NIA-AA research framework: toward a biological definition of Alzheimer's disease.Alzheimers Dement. 2018; 14: 535-562
- Evaluation of a radiolabelled peripheral benzodiazepine receptor ligand in the central nervous system inflammation of experimental autoimmune encephalomyelitis: a possible probe for imaging multiple sclerosis.Eur J Nucl Med Mol Imaging. 2005; 32: 557-563
- Evaluation of the PBR/TSPO radioligand [18F]DPA-714 in a rat model of focal cerebral ischemia.J Cereb Blood Flow Metab. 2010; 30: 230-241
- PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy.EJNMMI Res. 2012; 2: 60
- Glial activation and glucose metabolism in a transgenic amyloid mouse model: a triple-tracer PET study.J Nucl Med. 2016; 57: 954-960
- Combined [18F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice.J Neuroinflammation. 2016; 13: 140
- In vivo imaging of microglial activation by positron emission tomography with [11C]PBR28 in the 5XFAD model of Alzheimer’s disease.Glia. 2016; 64: 993-1006
- Sifting through the surfeit of neuroinflammation tracers.J Cereb Blood Flow Metab. 2018; 38: 204-224
- Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: implications for brain imaging studies.J Cereb Blood Flow Metab. 2020; 40: 1061-1076
- Recent progress in the development of TSPO PET ligands for neuroinflammation imaging in neurological diseases.Nucl Med Mol Imaging. 2017; 51: 283-296
- Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.J Cereb Blood Flow Metab. 2010; 30: 1608-1618
- Mixed-affinity binding in humans with 18-kDa translocator protein ligands.J Nucl Med. 2011; 52: 24-32
- Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [18F]-FEPPA.J Cereb Blood Flow Metab. 2012; 32: 968-972
- Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors.Nucl Med Biol. 2008; 35: 305-314
- Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study.Lancet Psychiatry. 2018; 5: 339-347
- In vivo imaging of translocator protein in long-term cannabis users.JAMA Psychiatry. 2019; 76: 1305-1313
- Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.ACS Chem Neurosci. 2014; 5: 963-971
- 11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain. biomarkers consortium radioligand project team.J Nucl Med. 2017; 58: 320-325
- Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios.EJNMMI Res. 2017; 7: 84
- Anatomy of 18F-GE180, a failed radioligand for the TSPO protein.Eur J Nucl Med Mol Imaging. 2020; (Online ahead of print)https://doi.org/10.1007/s00259-020-04732-y
- Enhanced expression of peripheral benzodiazepine receptors in trimethyltin-exposed rat brain: a biomarker of neurotoxicity.Neurotoxicology. 1995; 16: 441-450
- The dual role of microglia in ALS: mechanisms and therapeutic.Front Aging Neurosci. 2017; https://doi.org/10.3389/fnagi.2017.00242
- Reactive astrocytes: production, function, and therapeutic potential.Immunity. 2017; 46: 957-967
- Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer's disease.Eur J Nucl Med Mol Imaging. 2019; 46: 2831-2847
- Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.Brain. 2017; 140: 2460-2474
- Monoamine oxidase-B in astrocytes.Glia. 1993; 8: 122-132
- Astroglial responses to amyloid-beta progression in a mouse model of alzheimer's disease.Mol Imaging Biol. 2018; 20: 605-614
- (2012) Evi-dence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG.J Nucl Med. 2012; 53: 37-46
- Classics in neuroimaging: development of PET tracers for imaging monoamine oxidases.ACS Chem Neurosci. 2019; 10: 1867-1871
- Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET.Science. 1987; 235: 481-485
- Mechanistic positron emission tomography studies: demonstration of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]L-deprenyl in living baboon brain.J Neurochem. 1988; 51: 1524-1534
- Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain.Nucl Med Biol. 2000; 27: 43-49
- Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping.J Nucl Med. 1995; 36: 1255-1262
- Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer's disease.Eur J Nucl Med Mol Imaging. 2019; 46: 348-356
- Pharmacokinetics of radiotracers in human plasma during positron emission tomography.Synapse. 1999; 34: 124-134
- Kinetic modeling of the monoamine oxidase B radioligand [11C]SL25.1188 in human brain with high-resolution positron emission tomography.J Cereb Blood Flow Metab. 2014; 34: 883-889
- Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B.J Label Compd Radiopharm. 2011; 54: 678-680
- Monoamine oxidase B total distribution volume in the prefrontal cortex of major depressive disorder: an [11C]SL25.1188 positron emission tomography study.JAMA Psychiatry. 2019; 76: 634-641
- Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression.Neuropsychopharmacology. 2004; 29: 2088-2096
- Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue.Curr Drug Targets. 2013; 14: 1225-1236
- Characterization of a rat model to study acute neuroinflammation on histopathological, biochemical and functional outcomes.J Neurosci Methods. 2005; 144: 183-191
- Effects of neuroinflammation on the regenerative capacity of brain stem cells.J Neurochem. 2011; 116: 947-956
- Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration.Int J Mol Sci. 2019; 20: 2293
- The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice.Pharmacogenomics J. 2009; 9: 116-126
- PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide.Nucl Med Biol. 2015; 42: 753-761
- The rat brain in stereotaxic coordinates.4th edition. Academic Press, San Diego (CA)1998
- Automated radiosynthesis of [(11)C]L-deprenyl-D2 and [(11)C]D-deprenyl using a commercial platform.Appl Radiat Isot. 2016; 110: 47-52
- Synthesis, in vitro and in vivo evaluation of 11C-O-methylated arylpiperazines as potential serotonin 1A (5-HT1A) receptor antagonist radiotracers.EJNMMI Radiopharm Chem. 2020; 5: 13
- Exact and approximate rebinning algorithms for 3-D PET data.IEEE Trans Med Imaging. 1997; 16: 145-158
- A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co-registered anatomical atlas: application to pharmacological MRI.Neuroimage. 2006; 15: 538-550
- Parametric imaging of ligand-receptor binding in PET using a simplified reference region model.Neuroimage. 1997; 6: 279-287
- Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study.Eur J Nucl Med Mol Imaging. 2015; 42: 1119-1132
- Evidence for astrocytosis in ALS demonstrated by [11C](L)-deprenyl-D2 PET.J Neurol Sci. 2007; 255: 17-22
- In vivo imaging of astrocytosis in Alzheimer's disease: an 11C-L-deuteriodeprenyl and PIB PET study.Eur J Nucl Med Mol Imaging. 2011; 38: 2202-2208
- A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.J Neurochem. 2007; 102: 2118-2131
- Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180.J Nucl Med. 2014; 55: 466-472
- A novel PET imaging probe for the detection and monitoring of translocator protein 18 kDa expression in pathological disorders.Sci Rep. 2016; 6: 20422
- Comparative evaluation of three TSPO PET radiotracers in a LPS-induced model of mild neuroinflammation in rats.Mol Imaging Biol. 2017; 19: 77-89
- Preclinical comparison study between [18F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation.Bioorg Med Chem Lett. 2018; 28: 2925-2929
- Spatiotemporal induction patterns of cytokine and related immune signal molecule mRNAs in response to intrastriatal injection of lipopolysaccharide.J Neuroimmunol. 2000; 106: 114-129
- The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system.Neurobiol Dis. 2000; 7: 429-447
- Striatal neuroinflammation promotes Parkinsonism in rats.PLoS One. 2009; 4: e5482
- Differential upregulation of the cannabinoid CB₂ receptor in neurotoxic and inflammation-driven rat models of Parkinson's disease.Exp Neurol. 2015; 269: 133-141
- Serial quantitative TSPO-targeted PET reveals peak microglial activation up to 2 weeks after an epileptogenic brain insult.J Nucl Med. 2016; 57: 1302-1308
- Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-(R)-PK11195 PET and MRI.J Cereb Blood Flow Metab. 2016; 37: 1251-1263
- Identification of brain regions predicting epilep- togenesis by serial [(18)F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe ep- ilepsy.Neuroimage Clin. 2017; 15: 35-44
- Temporal lobe epilepsy visualized with PET with 11C-L-deuterium-deprenyl–analysis of kinetic data.Acta Neurol Scand. 1998; 98: 224-231
- PET with 11C-deuterium-deprenyl and 18F-FDG in focal epilepsy.Acta Neurol Scand. 2001; 103: 360-366
- Ex vivo characterization of neuroinflammatory and neuroreceptor changes during epileptogenesis using candidate positron emission tomography biomarkers.Epilepsia. 2019; 60: 2325-2333
- Ring-closing synthesis of dibenzothiophene sulfonium salts and their use as leaving groups for aromatic (18)F-fluorination.J Am Chem Soc. 2018; 140: 11125-11132
- Radiosynthesis of (S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)benzo[d]isoxazol-3-yl] oxazolidin-2-[11C]one ([11C]SL25.1188), a novel radioligand for imaging monoamine oxidase-B with PET.J Label Compd Radiopharm. 2008; 51: 153-158
- [(11)C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: preclinical characterisation in nonhuman primate.Synapse. 2010; 64: 61-69
- Impact of species-dependent differences on screening, design, and development of MAO B inhibitors.J Med Chem. 2006; 49: 6264-6272
- Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging.J Neurosci. 2012; 32: 10809-10818
- Imaging of translocator protein upregulation is selective for pro-inflammatory polarized astrocytes and microglia.Glia. 2020; 68: 280-297
- Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding.J Cereb Blood Flow Metab. 2020; 40: 1242-1255
- Neurotoxic reactive astrocytes are induced by activated microglia.Nature. 2017; 541: 481-487
- Functional dissection of astrocyte-secreted proteins: implications in brain health and diseases.Prog Neurobiol. 2018; 162: 37-69
- PET imaging of microglial activation-beyond targeting TSPO.Molecules. 2018; 23: 607
- Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson's disease: an in vivo 11C-BU99008 PET study.Brain. 2019; 142: 3116-3128
- Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: effects of treatments with I1- and I2-imidazoline drugs.J Psychopharmacol. 2015; 29: 996-1012
- [18F]FEPPA a TSPO radioligand: optimized radiosynthesis and evaluation as a PET radiotracer for brain inflammation in a peripheral LPS-injected mouse model.Molecules. 2018; 23: 1375
Article info
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.